Srila Prabhupada - "The dogs may bark but the caravan continues on."

Srila Prabhupada had a favorite saying - "The dogs may bark loudly but the caravan continues on uninterrupted"

The purport is, we should ignore envious delusional materialists, mayavadis and impersonalists, who, after getting sick of seeking out pleasure in this material decaying temporary universe life after life, then attempts to free themselves from the frustration of everything here being in an eternal state of decay, decline by attempting to enter or merge their consciousness into "a void of nothingless and none existence".

They believe this is where their consciousness, existing only as an individual by being embodied in as a material body, merges back into the "all pervasive oneness" of the void, from where they believe their consciousness originates from, and again no longer exists. (This is actually a discription of Buddhism too)

A devotee compares "impersonalist and materialists" to those who commit suicide. This is because most impersonalist and mayavadis do not believe they are a soul and instead believe they ARE the gross material decaying bodily vessel they are actually in.

They therefore deny God, as well as the soul they eternally are that is trapped within each material bodily vessel they take in the material creation.

Taking to Mayavadi philosophy by denying one's eternal loving personal relationship with God, and denying one's own eternal identity as an individual jiva soul, is compared to committing spiritual suicide.

Once we choose to enter the material creation, we are bound by karma good and bad based on our actions.

Everything that comes to us (the soul) contained first in a subtle material body, and then being rewarded or punished with a gross material body, all stems from our past actions we chose to participate in.

The material body we are in, was in a sense, created by our own past pious and impious actions that are now visiting us in the form of this gross material bodily vessel.

Srila Bhaktivenode Thakur prayed to the Lord that he could always remain in presents of devotees while the past enormous bank balance build up of past pious and impious actions from billions of lives gradually unfolds on him.